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Make that happen. By the end of next year it will be evident how big.

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When stimulated by certain growth factors, HER2 causes cellular growth and division; in the absence of stimulation by the growth factor, the cell will normally stop growing. Between 25 and 30 of breast cancers overexpress the HER2 gene or its protein product, and overexpression of HER2 in breast cancer is associated with increased disease recurrence and worse prognosis. When trastuzumab binds to the HER2 in breast cancer cells that overexpress the receptor, trastuzumab prevents growth factors from being able to bind to and stimulate the receptors, effectively blocking the growth of the cancer cells.

I thought it was humorous and I did not mean to offend people who have different tastes in humour. Please believe that by saying this, I am only trying to help this situation. If I have made it worse, then I place myself at your mercy and humbly apologize if I have spoken out of line. Please forgive me if that is what I have done.

Mario Cuomo. They were competing to replace Abe Beame, the gnome-sized mayor who was elected because he was the crack comptrollerâuntil the city found out he couldnât count.]